Indications

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Read More

Prolia® is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture.

Prolia® is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture.

Prolia® is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body.

Prolia® is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Read Less

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For women with osteoporosis after menopause at high risk for fracture

Meet these women
who are taking control
of their osteoporosis

and reducing their risk of fracture with Prolia®

Hear about the impact of Prolia® for real patients withpostmenopausal osteoporosis at high risk for fracture

Meet Barbara, taking Prolia® since 2014

Barbara's first osteoporosis treatment helped set her on a path to stronger bones.

VIEW VIDEO TRANSCRIPT

Welcome aboard. My name is Barbara.

I was a flight attendant for over 40 years, and I like to go, go, go!

When I first heard that I had osteoporosis, I was concerned about it. I was concerned about running and falling, walking and falling and I felt I was getting older.

Osteoporosis is not reversible, but you can help it remain stable or improve somewhat.

And that’s why I’m taking the Prolia® shot. Getting it twice a year hasn’t been difficult for me.

I put it in my schedule every six months.

Wherever I’m at, I’m always active. I run outside. I’m a firm believer in keeping your body well and your mind. Some of my best thoughts have occurred when I’m running.

Prolia® was the first prescription medication my doctor recommended.

Every time I’ve taken the bone density test it has shown improvement, and for me side effects haven’t been an issue, but I understand not everyone may have the same experience.

As far as my grandchildren, I mean, I’m called “Glammy.” I’m not called “Nana,” or “Grandma,” I’m called “Glammy.”

And I want to live up to my name, so I can keep doing what I’m doing.

I want to continue on my active lifestyle and continue being “Glammy.”

Important Safety Information

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®(denosumab). Prolia® contains the same medicine as XGEVA®.

Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.

If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease-mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start PROLIA and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.

Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • spasms, twitches, or cramps in your muscles
  • numbness or tingling in your fingers, toes, or around your mouth

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia®. Talk with your doctor before starting Prolia® treatment. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Are taking medicine that can lower your blood calcium levels
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
  • You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
  • Tell your doctor right away if you become pregnant while taking Prolia®.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Please see Prolia® full Prescribing Information including Medication Guide.

I wanna be ready for whatever I decide is next for me.

Talk to your doctor about Prolia® and visit Prolia.com to see full Prescribing Information and Medication Guide.

Meet Anita, taking Prolia® since 2011

Anita's journey with postmenopausal osteoporosis changed when she switched to Prolia®.

VIEW VIDEO TRANSCRIPT

My family is one of the most important things to me and I love being able to create experiences with them that we’ll always remember.

Whether it’s going to national parks together or being able to travel to my grandchildren’s t-ball games to cheer them on. And I didn’t want that to come to an end.

I was diagnosed with postmenopausal osteoporosis in 2000; so I’ve been dealing with it for years.

I remember, I, I went for my annual exam at my OB/GYN and she said that I should get tested for osteoporosis.

I had a bone density test, a DXA scan. The results came back showing my lumbar 4 in my lower back had a T-score of -4.1. I had postmenopausal osteoporosis and a high risk for fracture.

I thought, what do I do now?

When you have osteoporosis, you’re more likely to break a bone—which I knew.

My family was also aware of the challenges of having postmenopausal osteoporosis. When we were together they would say, “Watch, Ma, watch.”

I hated having them worry constantly about me breaking a bone. That was a difficult time for me.

I had tried other treatments before, but I wasn’t seeing great results. I thought, with a -4 anything, I have to keep trying. So I talked to my doctor about Prolia®.

After I started treatment with Prolia®, I started getting some results.

I know that Prolia® works differently for everyone, but my scan showed improvement within that first year.

I was so happy that Prolia® was helping my bones get stronger—finally, I found the right treatment for me.

My mindset is, if I don’t get my shot of Prolia®, my bones may begin to get weak again.

Having strong bones is really important to me, so I keep up with my Prolia® treatment by getting my shot every 6 months and I take my calcium and my vitamin D, as directed by my doctor.

I’m doing well and I can’t wait for my next adventure with my family.

Here’s some important safety information you should know about Prolia®.

Indication

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Important Safety Information

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®(denosumab). Prolia® contains the same medicine as XGEVA®.

Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.

If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease-mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start PROLIA and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.

Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • spasms, twitches, or cramps in your muscles
  • numbness or tingling in your fingers, toes, or around your mouth

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia®. Talk with your doctor before starting Prolia® treatment. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Are taking medicine that can lower your blood calcium levels
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
  • You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
  • Tell your doctor right away if you become pregnant while taking Prolia®.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prolia® full Prescribing Information including Medication Guide.

Since I started treatment with Prolia®, my doctor says my scans are showing improvement in my bone density score.

One shot every 6 months works for me.

Maybe it could be right for someone else.

Meet Carole, taking Prolia® since 2015

Carole found her fit by switching to Prolia®.

VIEW VIDEO TRANSCRIPT

I’m a fifth generation Texan. I’ve lived here all my life. I love doing things around my house, like decorating and taking care of my garden. It helps keep me centered.

Especially back when I was first diagnosed with postmenopausal osteoporosis in 2012. I wasn’t fearful when I found out—that’s not how I am or how I raised my kids, but it did concern me.

Originally, I was going to my OB/GYN to treat my postmenopausal osteoporosis and my bone density score wasn’t where I wanted it to be. I just was not happy with that—the medicine wasn’t doing what it should’ve been.

It was during that time that I finally said, “Look, we’ve got to do something about this.” I lived by myself and I supported myself financially, I just couldn’t imagine what would happen if I broke a bone.

I’ve always been independent and I raised my kids to be that way, too. I didn’t want to have to depend on other people taking care of me, or my dog, if I broke a bone.

I knew that there had to be a treatment that could work for me and lessen my risk of having a fracture.

Oh, I was so tired of the complicated administration process and not seeing any results that I wanted from the medication I was on.

Right around this time, I remember seeing Prolia® in a magazine, and then again in a TV commercial. I wanted to know more about it so I went onto Prolia.com and I did my research. And based on what I learned from the website, I knew that Prolia® was definitely something I wanted to talk to my doctor about since it was just a shot every 6 months to help strengthen your bones.

That’s why I went to my doctor and I asked about Prolia®. We talked it over and my doctor agreed that switching to Prolia® would be good for me. In my mind, a shot every 6 months seems like the best option for my lifestyle and my bones. So that very next doctor’s visit, I started on Prolia®.

Since I’ve started on Prolia® I feel like I’ve finally started to take control of my postmenopausal osteoporosis. Now I can focus on things that matter to me— like taking a trip to go see my kids and my grandkids on the weekends. Prolia® has helped strengthen my bones and I plan to stick with it going forward.

Here’s some important safety information you should know about Prolia®.

Indication

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Important Safety Information

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®(denosumab). Prolia® contains the same medicine as XGEVA®.

Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.

If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease-mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start PROLIA and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.

Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • spasms, twitches, or cramps in your muscles
  • numbness or tingling in your fingers, toes, or around your mouth

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia®. Talk with your doctor before starting Prolia® treatment. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Are taking medicine that can lower your blood calcium levels
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
  • You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
  • Tell your doctor right away if you become pregnant while taking Prolia®.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prolia® full Prescribing Information including Medication Guide.

Now when I visit my doctor for my regular Prolia® shot every 6 months, it’s usually a quick follow-up. We chat about my bone density score and what’s new with me, and I use that time with my doctor to schedule my next shot of Prolia®.

I’m glad that I was my own advocate and discovered Prolia®. It feels good knowing that I’m moving in the right direction now.

Meet Rebecca, taking Prolia® since 2015

With a family history of osteoporosis, Rebecca was an advocate for her osteoporosis.

VIEW VIDEO TRANSCRIPT

My mother had very bad osteoporosis, but I always thought that, well, that’s her body, I won’t have that issue.

Some people don’t realize if your mom has osteoporosis, you have a higher chance of having it too.

I thought my bones are fine, I exercise, I eat right, I’m healthy. But still, I went ahead and asked my doctor to do a bone scan and found out that my bones weren’t as great as I thought they were.

When my results came back, my doctor told me I had osteopenia, and then a few years later, was postmenopausal, and I had osteoporosis.

And that time they recommended Prolia®.

Prolia® fits into my lifestyle very well, the same way I schedule other appointments during the year.

It’s easy to remember to do.

I focus on maintaining a healthy and active lifestyle, and I consider Prolia® a part of that because it helps strengthen and protect my bones from fracture.

When you’re thinking about having kids, you hear that ticking of the biological clock

And I feel like it’s the same type of feeling now as I look at retirement and my next few decades

When you think about the things that are left on your bucket list, the last thing you want to think about is breaking a bone.

I don’t want to think, oh should I take that trip or take that bike ride or climb those steps.

I want to do what I want to do.

Important Safety Information

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®(denosumab). Prolia® contains the same medicine as XGEVA®.

Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.

If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease-mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start PROLIA and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.

Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • spasms, twitches, or cramps in your muscles
  • numbness or tingling in your fingers, toes, or around your mouth

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia®. Talk with your doctor before starting Prolia® treatment. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Are taking medicine that can lower your blood calcium levels
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
  • You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
  • Tell your doctor right away if you become pregnant while taking Prolia®.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Please see Prolia® full Prescribing Information including Medication Guide.

I’m excited for me time. The prospect of putting myself first and having the time at this stage in my life to do what I want to do

Talk to your doctor about Prolia® and visit Prolia.com to see full Prescribing Information and Medication Guide.

WATCH MORE EXPERIENCES FROM REAL PATIENTS

Barbara, taking Prolia® (denosumab) since 2014

Meet Barbara

Barbara's first osteoporosis treatment helped set her on a path to stronger bones.

Anita, taking Prolia® (denosumab) since 2011

Meet Anita

Anita's journey with postmenopausal osteoporosis changed when she switched to Prolia®.

Carole, taking Prolia® (denosumab) since 2015

Meet Carole

Carole found her fit by
switching to Prolia®.

Rebecca, taking Prolia® (denosumab) since 2015

Meet Rebecca

With a family history of osteoporosis, Rebecca was an
advocate for her osteoporosis.

Patient testimonials represent individual experiences with Prolia®. Results may vary. The patients in these testimonials have been compensated for their time.

See below for even more experiences from real patients

Patient testimonials represent individual experiences with Prolia®. Results may vary.

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Discover if Prolia® is right for you

See if this treatment meets your needs by exploring the benefits and risks of Prolia®.

FIND OUT

Ask your doctor about Prolia®

Download a personalized discussion guide to start the conversation with your doctor.

GET THE GUIDE
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Important Safety Information

What is the most important information I should know about Prolia®?
If you receive Prolia, you should not receive XGEVA® (denosumab). Prolia contains the same medicine as XGEVA®.
Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.
If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start PROLIA and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.
Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:
Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.
Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.
Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.
Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia®. Talk with your doctor before starting Prolia® treatment. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.
Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.
Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.
Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.
Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.
Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.
Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat).

The most common side effects of Prolia® in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache.

The most common side effects of Prolia® in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Additionally, in Prolia®-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed.

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. 

Indications

Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Prolia® is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture.

Prolia® is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture.

Prolia® is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body.

Prolia® is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body.

Please see Prolia® full Prescribing Information and Medication Guide.

Important Safety Information

What is the most important information I should know about Prolia®?
If you receive Prolia, you should not receive XGEVA® (denosumab). Prolia contains the same medicine as XGEVA®.
Prolia® can cause serious side effects (including):
Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in  
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